Targeted Therapeutics

Liselo Labs‘ first product was the formulataton of an egg-extract and Turmeric fortified yogurt and syrup, containing active ingredients that are currently being evaluated in dietary trials in COVID-19 patients.

The active ingredients in Sankatana have been clinically demonstrated to act as anti-inflammatories, and as such, may rapidly alleviate symptoms such as coughing, headache, tightness of chest and difficulty breathing, which are common symptoms in diseases such as COVID-19, Influenza, Asthma and Pneumonia.

The modes-of-action of Sankatana ingredients include:

  • Anti-SARS-CoV-2 antibodies which may inhibit SARS-CoV-2 viruses from gaining entry into human cells (inhibits viral entry through binding to conserved regions of the SARS-CoV-2 spike protein responsible for viral entry and/or subsequent endosomal escape and hence cell entry.)
  • May reduce lung inflammation in patients with COVID-19 and alleviate allergies (Predicted reduction in severe mast cell activated immunopathology.) 
  • May assist with reducing systemic inflammation (predicted inhibition of NF-kB activation/dysregulation.)

The information generated from the use of this yogurt and syrup may facilitate a better understanding of SARS-CoV-2 infections and diseases caused by coronaviruses in general.

Patients with chronic allergies or who have tested positive for COVID-19 are requested to try the Sankatana formulation, and record the results online to assist us to evaluate its effects on the immune response.  The Sankatana yogurt is safe for consumption and can be made part of one’s daily diet/plan unless the patient has egg allergies. Sankatana contains extracts of commercially farmed eggs and a turmeric preparation formulated in our lab for efficient delivery of the active ingredients in the oral mucosa (mouth), esophagus (gullet), and upper intestinal tract (small intestine).

Why Birds?

Coronaviruses naturally infect some bird species which have developed resistance and protect their offspring through antibodies deposited into eggs.  We propose that similar protection can be naturally extended to humans through passive immunity.  Liselo labs have produced and characterized avian antibodies that directly bind to the receptor-binding domain(RBD) of SARS-CoV-2, and are able to neutralize viral entry in sVNT studies in-vitro.  Consequently, Liselo Labs has developed the Sankatana yogurt and syrup containing these antibodies that may hypothetically reduce the immune response triggered by COVID-19, and also directly target the virus to facilitate clearance.